Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area.
نویسندگان
چکیده
Throughout the day, cognitive performance is under the combined influence of circadian processes and homeostatic sleep pressure. Some people perform best in the morning, whereas others are more alert in the evening. These chronotypes provide a unique way to study the effects of sleep-wake regulation on the cerebral mechanisms supporting cognition. Using functional magnetic resonance imaging in extreme chronotypes, we found that maintaining attention in the evening was associated with higher activity in evening than morning chronotypes in a region of the locus coeruleus and in a suprachiasmatic area (SCA) including the circadian master clock. Activity in the SCA decreased with increasing homeostatic sleep pressure. This result shows the direct influence of the homeostatic and circadian interaction on the neural activity underpinning human behavior.
منابع مشابه
Comment on "Modafinil shifts human locus coeruleus to low-tonic, high-phasic activity during functional MRI" and "Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area".
Minzenberg et al. (Reports, 12 December 2008, p. 1700) and Schmidt et al. (Reports, 24 April 2009, p. 516) reported blood oxygen level-dependent (BOLD) responses in the human locus coeruleus (LC). Here, we show that these LC responses do not correspond to the anatomical location of the LC and present cautionary data concerning the quality of BOLD signals measured from the LC using standard func...
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ورودعنوان ژورنال:
- Science
دوره 324 5926 شماره
صفحات -
تاریخ انتشار 2009